Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells

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Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells.

N-myc2 and insulin-like growth factor II (IGF-II) are coordinately overexpressed in the great majority of altered hepatic foci, which are the earliest precancerous lesions observed in the liver of woodchuck hepatitis virus carrier woodchucks, and these genes continue to be overexpressed in hepatocellular carcinomas (HCCs). We have investigated the function of these genes in woodchuck hepatocarc...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1996

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.70.9.6260-6268.1996